Macrophages Impair TLR9 Agonist Antitumor Activity through Interacting with the Anti-PD-1 Antibody Fc Domain

Macrophages Impair TLR9 Agonist Antitumor Activity through Interacting with the Anti-PD-1 Antibody Fc Domain

Background. A combination of TLR9 agonists and an anti-PD-1 antibody has been reported to be effective in immunocompetent mice but the role of innate immunity has not yet been completely elucidated. Therefore, we investigated the contribution of the innate immune system to this combinatorial immunot...

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Bibliographic Details
Main Authors: Simone Camelliti, Valentino Le Noci, Francesca Bianchi, Chiara Storti, Francesca Arnaboldi, Alessandra Cataldo, Serena Indino, Elena Jachetti, Mariangela Figini, Mario Paolo Colombo, Andrea Balsari, Nicoletta Gagliano, Elda Tagliabue, Lucia Sfondrini, Michele Sommariva
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
ovarian cancer
Toll-like receptor 9 (TLR9)
CpG oligodeoxynucleotides (CpG-ODNs)
programmed cell death 1 (PD-1)
macrophages
Fc receptors
Online Access:https://www.mdpi.com/2072-6694/13/16/4081

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https://www.mdpi.com/2072-6694/13/16/4081

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