In Silico Study of Camptothecin-Based Pro-Drugs Binding to Human Carboxylesterase 2

In Silico Study of Camptothecin-Based Pro-Drugs Binding to Human Carboxylesterase 2

Pro-drugs, which ideally release their active compound only at the site of action, i.e., in a cancer cell, are a promising approach towards an increased specificity and hence reduced side effects in chemotherapy. A popular form of pro-drugs is esters, which are activated upon their hydrolysis. Since...

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Bibliographic Details
Main Authors: Frank Beierlein, Anselm H. C. Horn, Heinrich Sticht, Andriy Mokhir, Petra Imhof
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomolecules
Subjects:
pro-drug
camptothecin
human carboxylesterase
homology model
docking
molecular dynamics simulations
Online Access:https://www.mdpi.com/2218-273X/14/2/153

Internet

https://www.mdpi.com/2218-273X/14/2/153

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