KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins

KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins

Loss-of-function mutations in the KRIT1 gene are associated with the pathogenesis of cerebral cavernous malformations (CCMs), a major cerebrovascular disease still awaiting therapies. Accumulating evidence demonstrates that KRIT1 plays an important role in major redox-sensitive mechanisms, including...

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Bibliographic Details
Main Authors: Laura Cianfruglia, Andrea Perrelli, Claudia Fornelli, Alessandro Magini, Stefania Gorbi, Anna Maria Salzano, Cinzia Antognelli, Francesca Retta, Valerio Benedetti, Paola Cassoni, Carla Emiliani, Giovanni Principato, Andrea Scaloni, Tatiana Armeni, Saverio Francesco Retta
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Antioxidants
Subjects:
cerebral cavernous malformations
KRIT1
oxidative stress
altered redox homeostasis and signaling
oxidative post-translational modifications
protein S-glutathionylation
redox proteomics
mass spectrometry
Online Access:http://www.mdpi.com/2076-3921/8/1/27

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http://www.mdpi.com/2076-3921/8/1/27

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