A High Body Mass Index and the Vacuum Phenomenon Upregulate Pain-Related Molecules in Human Degenerated Intervertebral Discs

A High Body Mass Index and the Vacuum Phenomenon Upregulate Pain-Related Molecules in Human Degenerated Intervertebral Discs

Animal studies suggest that pain-related-molecule upregulation in degenerated intervertebral discs (IVDs) potentially leads to low back pain (LBP). We hypothesized that IVD mechanical stress and axial loading contribute to discogenic LBP’s pathomechanism. This study aimed to elucidate the relationsh...

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Bibliographic Details
Main Authors: Masayuki Miyagi, Kentaro Uchida, Sho Inoue, Shotaro Takano, Mitsufumi Nakawaki, Ayumu Kawakubo, Hiroyuki Sekiguchi, Toshiyuki Nakazawa, Takayuki Imura, Wataru Saito, Eiki Shirasawa, Akiyoshi Kuroda, Shinsuke Ikeda, Yuji Yokozeki, Yusuke Mimura, Tsutomu Akazawa, Masashi Takaso, Gen Inoue
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
discogenic low back pain
calcitonin gene-related peptide
microsomal prostaglandin E synthase-1
Online Access:https://www.mdpi.com/1422-0067/23/6/2973

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https://www.mdpi.com/1422-0067/23/6/2973

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