Efficient bioactive oligonucleotide‐protein conjugation for cell‐targeted cancer therapy

Efficient bioactive oligonucleotide‐protein conjugation for cell‐targeted cancer therapy

Abstract Oligonucleotide‐protein conjugates have important applications in biomedicine. Simple and efficient methods are described for the preparation of these conjugates. Specifically, we describe a new method in which a bifunctional linker is attached to thiol‐oligonucleotide to generate a reactiv...

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Bibliographic Details
Main Authors: Dr. Anna Aviñó, Dr. Ugutz Unzueta, Dr. María Virtudes Céspedes, Dr. Isolda Casanova, Dr. Esther Vázquez, Prof. Dr. Antonio Villaverde, Prof. Dr. Ramon Mangues, Prof. Dr. Ramon Eritja
Format: Article
Language:English
Published: Wiley-VCH 2019-03-01
Series:ChemistryOpen
Subjects:
Oligonucleotide-protein conjugate
nanoparticle protein
2’-deoxy-5-fluorouridine
polymers
lipids
Online Access:https://doi.org/10.1002/open.201900038

Internet

https://doi.org/10.1002/open.201900038

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