13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation and exhaustion

13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation and exhaustion

IntroductionNaïve T cells remain in an actively maintained state of quiescence until activation by antigenic signals, upon which they start to proliferate and generate effector cells to initiate a functional immune response. Metabolic reprogramming is essential to meet the biosynthetic demands of th...

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Main Authors: Alexander Kirchmair, Niloofar Nemati, Giorgia Lamberti, Marcel Trefny, Anne Krogsdam, Anita Siller, Paul Hörtnagl, Petra Schumacher, Sieghart Sopper, Adolf Sandbichler, Alfred Zippelius, Bart Ghesquière, Zlatko Trajanoski
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
13C tracer analysis
immunometabolism
RNA sequencing
differentiation
stem cell memory cells
exhaustion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267816/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267816/full

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