Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation

Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation

Abstract Intercellular communication between axons and Schwann cells is critical for attaining the complex morphological steps necessary for axon maturation. In the early onset motor neuron disease spinal muscular atrophy (SMA), many motor axons are not ensheathed by Schwann cells nor grow sufficien...

Full description

Bibliographic Details
Main Authors: Lingling Kong, Cera W. Hassinan, Florian Gerstner, Jannik M. Buettner, Jeffrey B. Petigrow, David O. Valdivia, Michelle H. Chan-Cortés, Amy Mistri, Annie Cao, Scott Alan McGaugh, Madeline Denton, Stephen Brown, Joshua Ross, Markus H. Schwab, Christian M. Simon, Charlotte J. Sumner
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Acta Neuropathologica Communications
Subjects:
Spinal muscular atrophy (SMA)
Motor axon
Neuregulin 1 type III (NRG1-III)
Conduction velocity
Neuromuscular junction (NMJ)
Online Access:https://doi.org/10.1186/s40478-023-01551-8

Internet

https://doi.org/10.1186/s40478-023-01551-8

Similar Items