Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

Abstract Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in vitro. Astrocytes are key players in supporting ne...

Full description

Bibliographic Details
Main Authors: Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Acta Neuropathologica Communications
Subjects:
Astrocytes
Cortical neurons
Mitochondria
Cisplatin
Miro-1
Online Access:http://link.springer.com/article/10.1186/s40478-020-00897-7

Internet

http://link.springer.com/article/10.1186/s40478-020-00897-7

Similar Items