CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

Glioblastoma multiforme (GBM) is a lethal brain tumor, characterized by enhanced proliferation and invasion, as well as increased vascularization and chemoresistance. The expression of the hyaluronan receptor CD44 has been shown to correlate with GBM progression and poor prognosis. Here, we sought t...

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Bibliographic Details
Main Authors: Constantinos Kolliopoulos, Mohamad Moustafa Ali, Casimiro Castillejo-Lopez, Carl-Henrik Heldin, Paraskevi Heldin
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
CD44
glioblastoma
RNA-sequence analysis
PDGF family members
hyaluronan biology
HAS2
Online Access:https://www.mdpi.com/2072-6694/14/15/3747

Internet

https://www.mdpi.com/2072-6694/14/15/3747

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