SLAM‐Drop‐seq reveals mRNA kinetic rates throughout the cell cycle

SLAM‐Drop‐seq reveals mRNA kinetic rates throughout the cell cycle

Abstract RNA abundance is tightly regulated in eukaryotic cells by modulating the kinetic rates of RNA production, processing, and degradation. To date, little is known about time‐dependent kinetic rates during dynamic processes. Here, we present SLAM‐Drop‐seq, a method that combines RNA metabolic l...

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Bibliographic Details
Main Authors: Haiyue Liu, Roberto Arsiè, Daniel Schwabe, Marcel Schilling, Igor Minia, Jonathan Alles, Anastasiya Boltengagen, Christine Kocks, Martin Falcke, Nir Friedman, Markus Landthaler, Nikolaus Rajewsky
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:Molecular Systems Biology
Subjects:
cell cycle
mRNA kinetics
single cells
temporal regulation
transcription and degradation
Online Access:https://doi.org/10.15252/msb.202211427

Internet

https://doi.org/10.15252/msb.202211427

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