Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity

Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity

In cancer cells, aerobic glycolysis rather than oxidative phosphorylation (OxPhos) is generally preferred for the production of ATP. In many cancers, highly expressed pyruvate dehydrogenase kinase 1 (PDK1) reduces the activity of pyruvate dehydrogenase (PDH) by inducing the phosphorylation of its E1...

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Bibliographic Details
Main Authors: Choong-Hwan Kwak, Ling Jin, Jung Ho Han, Chang Woo Han, Eonmi Kim, MyoungLae Cho, Tae-Wook Chung, Sung-Jin Bae, Se Bok Jang, Ki-Tae Ha
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
ilimaquinone
Warburg effect
pyruvate dehydrogenase kinase 1
glycolysis
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/17/6021

Internet

https://www.mdpi.com/1422-0067/21/17/6021

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