Brucella Dissociation Is Essential for Macrophage Egress and Bacterial Dissemination

It has long been observed that smooth Brucella can dissociate into rough mutants that are cytotoxic to macrophages. However, the in vivo biological significance and/or mechanistic de-tails of Brucella dissociation and cytotoxicity remain incomplete. In the current report, a plaque assay was develop...

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Bibliographic Details
Main Authors: Thomas A Ficht, Jianwu ePei, Melissa eKahl-McDonagh
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00023/full