Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands

Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands

The present study investigated the in vitro pharmacology of the human kappa opioid receptor using multiple assays, including calcium mobilization in cells expressing chimeric G proteins, the dynamic mass redistribution (DMR) label-free assay, and a bioluminescence resonance energy transfer (BRET) as...

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Bibliographic Details
Main Authors: Chiara Sturaro, Davide Malfacini, Michela Argentieri, Francine M. Djeujo, Erika Marzola, Valentina Albanese, Chiara Ruzza, Remo Guerrini, Girolamo Calo’, Paola Molinari
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
kappa opioid receptor
G protein-coupled receptor
label-free
BRET
calcium mobilization
biased agonism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.873082/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.873082/full

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