Antibacterial Activity and Pharmacokinetic Profile of a Promising Antibacterial Agent: 22-(2-Amino-phenylsulfanyl)-22-Deoxypleuromutilin

Antibacterial Activity and Pharmacokinetic Profile of a Promising Antibacterial Agent: 22-(2-Amino-phenylsulfanyl)-22-Deoxypleuromutilin

A new pleuromutilin derivative, 22-(2-amino-phenylsulfanyl)-22-deoxypleuromutilin (amphenmulin), has been synthesized and proved excellent in vitro and in vivo efficacy than that of tiamulin against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), suggesting this compound may l...

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Bibliographic Details
Main Authors: Xiangyi Zuo, Xi Fang, Zhaosheng Zhang, Zhen Jin, Gaolei Xi, Yahong Liu, Youzhi Tang
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
pleuromutilin
antibacterial activity
acute toxicity
pharmacokinetic
mrsa
Online Access:https://www.mdpi.com/1420-3049/25/4/878

Internet

https://www.mdpi.com/1420-3049/25/4/878

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