DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3β/mTOR Signaling

DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3β/mTOR Signaling

Accumulating evidences supported that knock-down of DHCR24 is linked to the pathological risk factors of AD, suggesting a potential role of DHCR24 in AD pathogenesis. However, the molecular mechanism link between DHCR24 and tauopathy remains unknown. Here, in order to elucidate the relationship betw...

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Bibliographic Details
Main Authors: Xiaojing Bai, Junfeng Wu, Mengqi Zhang, Yixuan Xu, Lijie Duan, Kai Yao, Jianfeng Zhang, Jimei Bo, Yongfei Zhao, Guoxiong Xu, Hengbing Zu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
DHCR24
hyperphosphorylation
autophagy
PI3-K
GSK3β
mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.513605/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.513605/full

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