Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: I. Optimization, Characterization, Brain Localization, and Cytotoxic Studies

Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: I. Optimization, Characterization, Brain Localization, and Cytotoxic Studies

Numerous neurological disorders have a pathophysiology that involves an increase in free radical production in the brain. Quercetin (QER) is a nutraceutical compound that shields the brain against oxidative stress-induced neurodegeneration. Nonetheless, its low oral bioavailability diminishes brain...

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Bibliographic Details
Main Authors: Mohammed H. Elkomy, Randa Mohammed Zaki, Omar A. Alsaidan, Mohammed Elmowafy, Ameeduzzafar Zafar, Khaled Shalaby, Mohamed A. Abdelgawad, Fatma I. Abo El-Ela, Mostafa E. Rateb, Ibrahim A. Naguib, Hussein M. Eid
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceutics
Subjects:
quercetin
transferosomes
brain targeting
CT scan
cytotoxicity
intranasal
Online Access:https://www.mdpi.com/1999-4923/15/7/1805

Internet

https://www.mdpi.com/1999-4923/15/7/1805

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