Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models

Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models

Abstract Background Chitinase-like proteins (CLPs) play a key role in immunosuppression under inflammatory conditions such as cancer. CLPs are enzymatically inactive and become neutralized upon binding of their natural ligand chitin, potentially reducing CLP-driven immunosuppression. We investigated...

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Bibliographic Details
Main Authors: Robbe Salembier, Caro De Haes, Julie Bellemans, Kristel Demeyere, Wim Van Den Broeck, Niek N. Sanders, Steven Van Laere, Traci R. Lyons, Evelyne Meyer, Jonas Steenbrugge
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Breast Cancer Research
Subjects:
Chitinase-like proteins
Chitin
Immunosuppression
Triple-negative breast cancer
Lymphatic metastasis
Immunotherapy
Online Access:https://doi.org/10.1186/s13058-024-01815-8

Internet

https://doi.org/10.1186/s13058-024-01815-8

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