Choline-Sigma-1R as an Additional Mechanism for Potentiation of Orexin by Cocaine

Choline-Sigma-1R as an Additional Mechanism for Potentiation of Orexin by Cocaine

Orexin A, an endogenous peptide involved in several functions including reward, acts via activation of orexin receptors OX<sub>1</sub> and OX<sub>2</sub>, Gq-coupled GPCRs. We examined the effect of a selective OX<sub>1</sub> agonist, OXA (17-33) on cytosolic calc...

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Bibliographic Details
Main Authors: Jeffrey L. Barr, Pingwei Zhao, G. Cristina Brailoiu, Eugen Brailoiu
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
choline
orexin A
OX<sub>1</sub> receptor
phospholipase D
PLD
reward
Online Access:https://www.mdpi.com/1422-0067/22/10/5160

Internet

https://www.mdpi.com/1422-0067/22/10/5160

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