Chronic Ouabain Targets Pore-Forming Claudin-2 and Ameliorates Radiation-Induced Damage to the Rat Intestinal Tissue Barrier

Chronic Ouabain Targets Pore-Forming Claudin-2 and Ameliorates Radiation-Induced Damage to the Rat Intestinal Tissue Barrier

Ionizing radiation (IR) causes disturbances in the functions of the gastrointestinal tract. Given the therapeutic potential of ouabain, a specific ligand of the Na,K-ATPase, we tested its ability to protect against IR-induced disturbances in the barrier and transport properties of the jejunum and co...

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Bibliographic Details
Main Authors: Alexander G. Markov, Alexandra A. Livanova, Arina A. Fedorova, Violetta V. Kravtsova, Igor I. Krivoi
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
ionizing radiation
ouabain
epithelium
tight junctions
claudins
gastrointestinal acute radiation syndrome
Online Access:https://www.mdpi.com/1422-0067/25/1/278

Internet

https://www.mdpi.com/1422-0067/25/1/278

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