CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway

CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway

Hydrogen sulfide (H2S), a gasotransmitter with protective effects in the cardiovascular system, is endogenously generated by three main enzymatic pathways: cystathionine gamma lyase (CTH), cystathionine beta synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) enzymes. CTH and MPST are the...

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Bibliographic Details
Main Authors: Antonia Katsouda, Maria Markou, Paraskevas Zampas, Aimilia Varela, Constantinos H. Davos, Valentina Vellecco, Giuseppe Cirino, Mariarosaria Bucci, Andreas Papapetropoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
cystathine γ-lyase
mercaptopyruvate sulfurtransferase
blood pressure
vasorelaxation
nitric oxide synthase
hydrogen sulfide
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1090654/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1090654/full

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