Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

Abstract Liver injury triggers adaptive remodeling of the hepatic transcriptome for repair/regeneration. We demonstrate that this involves particularly profound transcriptomic alterations where acute induction of genes involved in handling of endoplasmic reticulum stress (ERS) is accompanied by part...

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Bibliographic Details
Main Authors: Vanessa Dubois, Céline Gheeraert, Wouter Vankrunkelsven, Julie Dubois‐Chevalier, Hélène Dehondt, Marie Bobowski‐Gerard, Manjula Vinod, Francesco Paolo Zummo, Fabian Güiza, Maheul Ploton, Emilie Dorchies, Laurent Pineau, Alexis Boulinguiez, Emmanuelle Vallez, Eloise Woitrain, Eric Baugé, Fanny Lalloyer, Christian Duhem, Nabil Rabhi, Ronald E van Kesteren, Cheng‐Ming Chiang, Steve Lancel, Hélène Duez, Jean‐Sébastien Annicotte, Réjane Paumelle, Ilse Vanhorebeek, Greet Van den Berghe, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Format: Article
Language:English
Published: Springer Nature 2020-05-01
Series:Molecular Systems Biology
Subjects:
liver injury
NFIL3
PAR‐bZIP
sepsis
super‐enhancer
Online Access:https://doi.org/10.15252/msb.20199156

Internet

https://doi.org/10.15252/msb.20199156

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