Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K+ channels

Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K+ channels

A search in the GDC Data Portal revealed 304 documented somatic mutations of the KCNJ3 gene in primary tumors (out of 10.202 cases). Most affected tumor types were carcinomas from uterus, skin and lung, while breast cancer exerted the lowest number of somatic mutations. We focused our research on 15...

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Bibliographic Details
Main Authors: Brigitte Pelzmann, Ahmed Hatab, Susanne Scheruebel, Sonja Langthaler, Theresa Rienmueller, Armin Sokolowski, Astrid Gorischek, Dieter Platzer, Klaus Zorn-Pauly, Stephan W. Jahn, Thomas Bauernhofer, Wolfgang Schreibmayer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
ion channels and cancer
GIRK1
somatic mutation analysis
Xenopus laevis (X. laevis)
confocal laser scanning microcopy
two electrode voltage clamp
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.998907/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.998907/full

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