A Water-Soluble Chitosan Derivative for the Release of Bioactive Deferoxamine

A Water-Soluble Chitosan Derivative for the Release of Bioactive Deferoxamine

Deferoxamine (DFO) is a water-soluble iron chelator used pharmacologically for the management of patients with transfusional iron overload. However, DFO is not cell-permeable and has a short plasma half-life, which necessitates lengthy parenteral administration with an infusion pump. We previously r...

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Bibliographic Details
Main Authors: Georgia Michailidou, Yupeng Li, Alexandra Zamboulis, Georgia Karlioti, Despoina Meimaroglou, Kostas Pantopoulos, Dimitrios N. Bikiaris
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
deferoxamine
beta-thalassemia
chitosan
drug release
nanoparticles
solid dispersion
Online Access:https://www.mdpi.com/1422-0067/25/2/913

Internet

https://www.mdpi.com/1422-0067/25/2/913

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