Involvement of MT2 receptors in protective effects of melatonin against cisplatin-induced gastrointestinal damage in mice

Involvement of MT2 receptors in protective effects of melatonin against cisplatin-induced gastrointestinal damage in mice

Abstract Melatonin (MLT) reportedly reduces side effects associated with certain antineoplastic agents. Accordingly, we investigated the effect of MLT on cisplatin (CP)-induced gastric emptying (GE) delay. Mice were intraperitoneally pretreated with vehicle (ethanol 5%; control group), MLT (5, 10, o...

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Bibliographic Details
Main Authors: Anita Eugenia Alencar Santos Ribeiro, Eliane Feitosa Ferreira, Jaknea dos Santos Leal, Ricássio de Sousa Barberino, Helinando Pequeno de Oliveira, Raimundo Campos Palheta Junior
Format: Article
Language:English
Published: Universidade de São Paulo 2022-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Gastric emptying
Gut motility
Gastrointestinal
Chemotherapy
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100776&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100776&tlng=en

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