Physiological Roles of the Autoantibodies to the 78-Kilodalton Glucose-Regulated Protein (GRP78) in Cancer and Autoimmune Diseases

Physiological Roles of the Autoantibodies to the 78-Kilodalton Glucose-Regulated Protein (GRP78) in Cancer and Autoimmune Diseases

The 78 kDa glucose-regulated protein (GRP78), a member of the 70 kDa heat-shock family of molecular chaperones (HSP70), is essential for the regulation of the unfolded protein response (UPR) resulting from cellular endoplasmic reticulum (ER) stress. During ER stress, GRP78 evades retention mechanism...

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Bibliographic Details
Main Authors: Mario Gonzalez-Gronow, Salvatore Vincent Pizzo
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
cancer
autoimmune diseases
ER dysfunctions
GRP78 autoantigenicity
GRP78 cell surface compartments
GRP78 citrullination
Online Access:https://www.mdpi.com/2227-9059/10/6/1222

Internet

https://www.mdpi.com/2227-9059/10/6/1222

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