HTLV-1 Hbz protein, but not hbz mRNA secondary structure, is critical for viral persistence and disease development.

HTLV-1 Hbz protein, but not hbz mRNA secondary structure, is critical for viral persistence and disease development.

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic cause of adult T-cell leukemia/lymphoma (ATL) and encodes a viral oncoprotein (Hbz) that is consistently expressed in asymptomatic carriers and ATL patients, suggesting its importance in the development and maintenance of HTLV-1 leukemic c...

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Bibliographic Details
Main Authors: Victoria Maksimova, Tasha Wilkie, Susan Smith, Cameron Phelps, Corrine Melvin, Lianbo Yu, Stefan Niewiesk, Patrick L Green, Amanda R Panfil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011459

Internet

https://doi.org/10.1371/journal.ppat.1011459

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