Role and mechanism of FOXG1-related epigenetic modifications in cisplatin-induced hair cell damage

Role and mechanism of FOXG1-related epigenetic modifications in cisplatin-induced hair cell damage

Cisplatin is widely used in clinical tumor chemotherapy but has severe ototoxic side effects, including tinnitus and hearing damage. This study aimed to determine the molecular mechanism underlying cisplatin-induced ototoxicity. In this study, we used CBA/CaJ mice to establish an ototoxicity model o...

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Bibliographic Details
Main Authors: Yu-rong Mu, Sheng-yu Zou, Ming Li, Yan-yan Ding, Xiang Huang, Zu-hong He, Wei-jia Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cisplatin
ototoxicity
hair cells
FOXG1
epigenetics
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1064579/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1064579/full

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