A Comprehensive Bioinformatic Analysis of RNA-seq Datasets Reveals a Differential and Variable Expression of Wildtype and Variant UGT1A Transcripts in Human Tissues and Their Deregulation in Cancers

A Comprehensive Bioinformatic Analysis of RNA-seq Datasets Reveals a Differential and Variable Expression of Wildtype and Variant UGT1A Transcripts in Human Tissues and Their Deregulation in Cancers

The <i>UGT1A</i> locus generates over 60 different alternatively spliced transcripts and 30 circular RNAs. To date, v2 and v3 transcripts are the only variant UGT1A transcripts that have been functionally characterized. Both v2 and v3 transcripts encode the same inactive variant UGT1A pr...

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Bibliographic Details
Main Authors: Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Ross A. McKinnon, Peter I. Mackenzie, Robyn Meech
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cancers
Subjects:
glucuronosyltransferase
cancer
alternative splicing
differential expression
deregulation
drug metabolism
Online Access:https://www.mdpi.com/2072-6694/16/2/353

Internet

https://www.mdpi.com/2072-6694/16/2/353

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