Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis

Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis

The early life environment significantly affects the development of age-related skeletal muscle disorders. However, the long-term effects of lactational protein restriction on skeletal muscle are still poorly defined. Our study revealed that male mice nursed by dams fed a low-protein diet during lac...

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Bibliographic Details
Main Authors: Ufuk Ersoy, Ioannis Kanakis, Moussira Alameddine, Gibran Pedraza-Vazquez, Susan E. Ozanne, Mandy Jayne Peffers, Malcolm J. Jackson, Katarzyna Goljanek-Whysall, Aphrodite Vasilaki
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Redox Biology
Subjects:
Skeletal muscle
Sarcopenia
Maternal nutrition
Protein restriction
Proteostasis
Mitochondrial homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723003816

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http://www.sciencedirect.com/science/article/pii/S2213231723003816

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