Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches

Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches

Abstract The study of tumorigenic rewiring of metabolic flux is at the heart of cancer metabolic research. Here, we review two widely used computational flux inference approaches: isotope tracing coupled with Metabolic Flux Analysis (13C-MFA) and COnstraint-Based Reconstruction and Analysis (COBRA)....

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Bibliographic Details
Main Authors: Shoval Lagziel, Won Dong Lee, Tomer Shlomi
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Biology
Subjects:
Cancer metabolism
Metabolic network modeling
Metabolic flux analysis
Constraint-based modeling
COBRA
Isotope tracing
Online Access:http://link.springer.com/article/10.1186/s12915-019-0669-x

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http://link.springer.com/article/10.1186/s12915-019-0669-x

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