Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature

Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature

Abstract Normal breast luminal epithelial progenitors have been implicated as cell of origin in basal-like breast cancer, but their anatomical localization remains understudied. Here, we combine collection under the microscope of organoids from reduction mammoplasties and single-cell mRNA sequencing...

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Bibliographic Details
Main Authors: Katharina Theresa Kohler, Nadine Goldhammer, Samuel Demharter, Ulrich Pfisterer, Konstantin Khodosevich, Lone Rønnov-Jessen, Ole William Petersen, René Villadsen, Jiyoung Kim
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00444-8

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https://doi.org/10.1038/s41523-022-00444-8

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