In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasi and L (Viannia) braziliensis

In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasi and L (Viannia) braziliensis

The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fiocruz, Brazil (TAMs), was assessed and compared to Glucantime®-Aventis Pharma Ltda. Using the amastigote-like in vitro model, the active concentrations of Sb v varied from 10µg/ml to 300 µg/ml for L. (L...

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Bibliographic Details
Main Authors: Eliane de Morais-Teixeira, Alcione S de Carvalho, Jorge CS da Costa, Silvio L Duarte, Jorge S Mendonça, Núbia Boechat, Ana Rabello
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2008-06-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
leishmaniasis
treatment
meglumine antimoniate
in vitro
in vivo
drug evaluation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000400008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000400008

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