Polyethylene Glycol‐Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart

Polyethylene Glycol‐Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart

Abstract Protein therapeutics, except for antibodies, have a short plasma half‐life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PEG is immunogenic. In addition to induced PEG antibod...

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Bibliographic Details
Main Authors: Imran Ozer, Garrett Kelly, Renpeng Gu, Xinghai Li, Nikita Zakharov, Parul Sirohi, Smita K. Nair, Joel H. Collier, Michael S. Hershfield, Angus M. Hucknall, Ashutosh Chilkoti
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Advanced Science
Subjects:
antigenicity
immunogenicity
pegloticase
pharmacokinetics
polyethylene glycol
polyethylene glycol antibody
Online Access:https://doi.org/10.1002/advs.202103672

Internet

https://doi.org/10.1002/advs.202103672

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