Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing

Prime editing is a next-generation approach for precision genome engineering. Here the authors design a nuclease-based prime editor that leverages DNA repair pathways for targeted genomic insertions.

Bibliographic Details
Main Authors: Martin Peterka, Nina Akrap, Songyuan Li, Sandra Wimberger, Pei-Pei Hsieh, Dmitrii Degtev, Burcu Bestas, Jack Barr, Stijn van de Plassche, Patricia Mendoza-Garcia, Saša Šviković, Grzegorz Sienski, Mike Firth, Marcello Maresca
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28771-1

Internet

https://doi.org/10.1038/s41467-022-28771-1

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