Dual-Armed Oncolytic Myxoma Virus Encoding IFN-γ and CD47 Promotes Lymphocyte Infiltration and Tumor Suppression of Syngeneic Murine Melanoma

Dual-Armed Oncolytic Myxoma Virus Encoding IFN-γ and CD47 Promotes Lymphocyte Infiltration and Tumor Suppression of Syngeneic Murine Melanoma

Myxoma virus (MyxV) is a rabbit-specific poxvirus. However, its ability to selectively target tumor cells has established it as a safe and effective anticancer therapy. To strengthen its preclinical efficacy, transgenes that can prolong cancer cell infection and enhance anti-tumor effector functions...

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Bibliographic Details
Main Authors: Jong Kyu Woo, Tae-Geuk Kim, Na Yeon Im, Ka-Yeon Son, Minhyeon Cho, Yeo Jin Jeong, Jeong-Im Hong, BoRim Kang, Gansukh Enkhtaivan, Nam-Hyuk Cho, Tommy Alain, Dong Guk Park, Yeon-Sook Lee
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cancers
Subjects:
oncolytic virus
Armed-Myxoma virus
CD47
IFN-γ
tumor-infiltrating lymphocytes (TIL)
Foxp3+ CD4+ regulatory T-cell (T-reg)
Online Access:https://www.mdpi.com/2072-6694/15/19/4703

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https://www.mdpi.com/2072-6694/15/19/4703

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