SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

Summary: The intestine is a highly metabolic tissue, but the metabolic programs that influence intestinal crypt proliferation, differentiation, and regeneration are still emerging. Here, we investigate how mitochondrial sirtuin 4 (SIRT4) affects intestinal homeostasis. Intestinal SIRT4 loss promotes...

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Bibliographic Details
Main Authors: Sarah A. Tucker, Song-Hua Hu, Sejal Vyas, Albert Park, Shakchhi Joshi, Aslihan Inal, Tiffany Lam, Emily Tan, Kevin M. Haigis, Marcia C. Haigis
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724003036

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http://www.sciencedirect.com/science/article/pii/S2211124724003036

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