Evaluation of mode of indoleamine 2,3-dioxygenase 1 inhibition by 4,7-dichloroquinolines

Evaluation of mode of indoleamine 2,3-dioxygenase 1 inhibition by 4,7-dichloroquinolines

Herein, we report the development of synthetically simpler analogs of 4,7-dichloroquinoline (DCQ) as apo-indoleamine 2,3-dioxygenase 1(IDO1) protein targeting ligand to inhibit the activity of IDO1 enzyme. Derivatization of the DCQ moiety improved the IDO1 inhibitory activity both against purified e...

Full description

Bibliographic Details
Main Authors: Niku Moni Das, Biswa Mohan Prusty, Nirmalya Pradhan, Anjali Gupta, Miguel Carmena-Bargueño, Rama Karn, Horacio Pérez-Sánchez, Sachin Kumar, Debasis Manna
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Apo-IDO1 binding
4,7-Dichloroquinoline
Dual activity
Heme-binding
IDO1 inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417423000109

Internet

http://www.sciencedirect.com/science/article/pii/S2772417423000109

Similar Items