IL‐17 drives salivary gland dysfunction via inhibiting TRPC1‐mediated calcium movement in Sjögren’s syndrome

IL‐17 drives salivary gland dysfunction via inhibiting TRPC1‐mediated calcium movement in Sjögren’s syndrome

Abstract Objectives This study aims to determine a role of interleukin‐17A (IL‐17) in salivary gland (SG) dysfunction and therapeutic effects of targeting IL‐17 in SG for treating autoimmune sialadenitis in primary Sjögren’s syndrome (pSS). Methods Salivary IL‐17 levels and IL‐17‐secreting cells in...

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Bibliographic Details
Main Authors: Fan Xiao, Wenhan Du, Xiaoxia Zhu, Yuan Tang, Lixiong Liu, Enyu Huang, Chong Deng, Cainan Luo, Man Han, Ping Chen, Liping Ding, Xiaoping Hong, Lijun Wu, Quan Jiang, Hejian Zou, Dongzhou Liu, Liwei Lu
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
autoimmune sialadenitis
calcium movement
IL‐17
primary Sjögren’s syndrome
salivary dysfunction
Online Access:https://doi.org/10.1002/cti2.1277

Internet

https://doi.org/10.1002/cti2.1277

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