Hemin-incorporating DNA nanozyme enabling catalytic oxygenation and GSH depletion for enhanced photodynamic therapy and synergistic tumor ferroptosis

Hemin-incorporating DNA nanozyme enabling catalytic oxygenation and GSH depletion for enhanced photodynamic therapy and synergistic tumor ferroptosis

Abstract Photodynamic therapy (PDT) has emerged as a promising tumor treatment method via light-triggered generation of reactive oxygen species (ROS) to kill tumor cells. However, the efficacy of PDT is usually restricted by several biological limitations, including hypoxia, excess glutathione (GSH)...

Full description

Bibliographic Details
Main Authors: Xiaoxiong Xiao, Min Chen, Yuchen Zhang, Liang Li, Ying Peng, Wenhu Zhou, Junyu Li
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Nanobiotechnology
Subjects:
Nanomedicine
DNAzyme
Aptamer
Targeting
Phototherapy
Tumor hypoxia
Online Access:https://doi.org/10.1186/s12951-022-01617-0

Internet

https://doi.org/10.1186/s12951-022-01617-0

Similar Items