Exome-wide association study of treatment-resistant depression suggests novel treatment targets

Abstract Treatment-resistant depression (TRD) is a severe form of major depressive disorder (MDD) with substantial public health impact and poor treatment outcome. Treatment outcome in MDD is significantly heritable, but genome-wide association studies have failed to identify replicable common marke...

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Bibliographic Details
Main Authors: Shrey B. Shah, Teja N. Peddada, Christopher Song, Maame Mensah, Heejong Sung, Mani Yavi, Peixiong Yuan, Carlos A. Zarate, Brian J. Mickey, Margit Burmeister, Nirmala Akula, Francis J. McMahon
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-38984-z