Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer

Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer

Abstract Background The screening biomarkers for early detection of colorectal cancer (CRC) is lacking. The aim is to identify epigenetic silenced genes and clarify its roles and underlying mechanism in CRC. We conducted integrative analyses of epigenome-wide Human Methylation 450 K arrays and trans...

Full description

Bibliographic Details
Main Authors: Zixu Yuan, Xihu Yu, Wenle Chen, Daici Chen, Jian Cai, Yingming Jiang, Xiaoxia Liu, Zhijie Wu, Lei Wang, William M. Grady, Hui Wang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Cell Communication and Signaling
Subjects:
HAND2
Epigenetics
Colorectal cancer
ERK signaling
Online Access:https://doi.org/10.1186/s12964-022-00878-4

Internet

https://doi.org/10.1186/s12964-022-00878-4

Similar Items