Activation of Piezo1 or TRPV2 channels inhibits human ureteral contractions via NO release from the mucosa

Activation of Piezo1 or TRPV2 channels inhibits human ureteral contractions via NO release from the mucosa

We aimed to investigate the expression and motor modulatory roles of several mechano-sensitive channels (MSCs) in human ureter. Human proximal ureters were obtained from eighty patients subjected to nephrectomy. Expression of MSCs at mRNA, protein and functional levels were examined. Contractions of...

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Bibliographic Details
Main Authors: Jianing Liu, Cong Wang, Wenyu Wang, Ning Ding, Jiaxin Liu, Hanwen Liu, Jiliang Wen, Wendong Sun, Shulu Zu, Xiulin Zhang, Jieke Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Pharmacology
Subjects:
mechano-sensitive channels
mucosa
Piezo1 channel
TRPV2 channel
ureteral motility
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1410565/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1410565/full

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