Purification of Human CD34+CD90+ HSCs Reduces Target Cell Population and Improves Lentiviral Transduction for Gene Therapy

Purification of Human CD34+CD90+ HSCs Reduces Target Cell Population and Improves Lentiviral Transduction for Gene Therapy

Hematopoietic stem cell (HSC) gene therapy has the potential to cure many genetic, malignant, and infectious diseases. We have shown in a nonhuman primate gene therapy and transplantation model that the CD34+CD90+ cell fraction was exclusively responsible for multilineage engraftment and hematopoiet...

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Bibliographic Details
Main Authors: Stefan Radtke, Dnyanada Pande, Margaret Cui, Anai M. Perez, Yan-Yi Chan, Mark Enstrom, Stefanie Schmuck, Andrew Berger, Tom Eunson, Jennifer E. Adair, Hans-Peter Kiem
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
Hematopoietic Stem Cells
Gene Therapy
CD90 CD34
Lentivirus Transduction
Stem Cell Enrichment / Cell Sorting
single cell RNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301595

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http://www.sciencedirect.com/science/article/pii/S2329050120301595

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