The U-Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell-Dependent Manner

The U-Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell-Dependent Manner

ABSTRACT Hepatitis E virus (HEV), a single-strand positive-sense RNA virus, is an understudied but important human pathogen. The virus can establish infection at a number of host tissues, including the small intestine and liver, causing acute and chronic hepatitis E as well as certain neurological d...

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Bibliographic Details
Main Authors: Harini Sooryanarain, Connie L. Heffron, Xiang-Jin Meng
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
hepatitis E virus (HEV)
U-rich region RNA PAMPs
retinoic acid-inducible gene I (RIG-I)
type I interferon (IFN)
type-III IFN
Online Access:https://journals.asm.org/doi/10.1128/mBio.03103-19

Internet

https://journals.asm.org/doi/10.1128/mBio.03103-19

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