Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles

Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles

Abstract Background The cause of the motor neuron (MN) death that drives terminal pathology in amyotrophic lateral sclerosis (ALS) remains unknown, and it is thought that the cellular environment of the MN may play a key role in MN survival. Several lines of evidence implicate vesicles in ALS, inclu...

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Bibliographic Details
Main Authors: Laura Le Gall, William J. Duddy, Cecile Martinat, Virginie Mariot, Owen Connolly, Vanessa Milla, Ekene Anakor, Zamalou G. Ouandaogo, Stephanie Millecamps, Jeanne Lainé, Udaya Geetha Vijayakumar, Susan Knoblach, Cedric Raoul, Olivier Lucas, Jean Philippe Loeffler, Peter Bede, Anthony Behin, Helene Blasco, Gaelle Bruneteau, Maria Del Mar Amador, David Devos, Alexandre Henriques, Adele Hesters, Lucette Lacomblez, Pascal Laforet, Timothee Langlet, Pascal Leblanc, Nadine Le Forestier, Thierry Maisonobe, Vincent Meininger, Laura Robelin, Francois Salachas, Tanya Stojkovic, Giorgia Querin, Julie Dumonceaux, Gillian Butler Browne, Jose‐Luis González De Aguilar, Stephanie Duguez, Pierre Francois Pradat
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Secreted vesicles
Cell–cell communication
MND
sporadic ALS
Online Access:https://doi.org/10.1002/jcsm.12945

Internet

https://doi.org/10.1002/jcsm.12945

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