Global Analysis of <i>Plasmodium falciparum</i> Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study

Global Analysis of <i>Plasmodium falciparum</i> Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study

The continual rise in sulfadoxine (SDX) resistance affects the therapeutic efficacy of sulfadoxine-pyrimethamine; therefore, careful monitoring will help guide its prolonged usage. Mutations in <i>Plasmodium falciparum</i> dihydropteroate synthase (<i>Pf</i>dhps) are being su...

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Bibliographic Details
Main Authors: Rita Afriyie Boateng, James L. Myers-Hansen, Nigel N. O. Dolling, Benedicta A. Mensah, Elia Brodsky, Mohit Mazumder, Anita Ghansah
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
<i>Pf</i>dhps
sulfadoxine resistance
malaria
molecular dynamics simulations
molecular docking
haplotype
Online Access:https://www.mdpi.com/1420-3049/28/1/145

Internet

https://www.mdpi.com/1420-3049/28/1/145

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