Clinical utility of Next Generation Sequencing of plasma cell-free DNA for the molecular profiling of patients with NSCLC at diagnosis and disease progression

Clinical utility of Next Generation Sequencing of plasma cell-free DNA for the molecular profiling of patients with NSCLC at diagnosis and disease progression

Background: The present study evaluates the utility of NGS analysis of circulating free DNA (cfDNA), which incorporates small amounts of tumor DNA (ctDNA), at diagnosis or at disease progression (PD) in NSCLC patients. Methods: Comprehensive genomic profiling on cfDNA by NGS were performed in NSCLC...

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Bibliographic Details
Main Authors: Marzia Del Re, Giovanna Irene Luculli, Iacopo Petrini, Andrea Sbrana, Vieri Scotti, Diego de Miguel Perez, Lorenzo Livi, Stefania Crucitta, Mauro Iannopollo, Francesca Mazzoni, Martina Ruglioni, Carmelo Tibaldi, Emanuela Olmetto, Irene Stasi, Editta Baldini, Giacomo Allegrini, Lorenzo Antonuzzo, Franco Morelli, Andrea Pierini, Nicola Panzeri, Stefano Fogli, Antonio Chella, Christian Rolfo, Romano Danesi
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Translational Oncology
Subjects:
Liquid biopsy
NGS
NSCLC
Predictive biomarkers
Resistance to treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323002553

Internet

http://www.sciencedirect.com/science/article/pii/S1936523323002553

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