HMGB1-promoted and TLR2/4-dependent NK cell maturation and activation take part in rotavirus-induced murine biliary atresia.

HMGB1-promoted and TLR2/4-dependent NK cell maturation and activation take part in rotavirus-induced murine biliary atresia.

Recent studies show that NK cells play important roles in murine biliary atresia (BA), and a temporary immunological gap exists in this disease. In this study, we found high-mobility group box-1 (HMGB1) and TLRs were overexpressed in human and rotavirus-induced murine BA. The overexpressed HMGB1 rel...

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Bibliographic Details
Main Authors: Yinrong Qiu, Jixin Yang, Wenmei Wang, Wentao Zhao, Fei Peng, Ying Xiang, Gang Chen, Tao Chen, Chengwei Chai, Shuaiyu Zheng, Daniel J Watkins, Jiexiong Feng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3961347?pdf=render

Internet

http://europepmc.org/articles/PMC3961347?pdf=render

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