Ultra-processed food consumption and associations with biomarkers of nutrition and inflammation in pregnancy: The Norwegian Environmental Biobank
BackgroundA high consumption of ultra-processed foods (UPFs) is often associated with low nutritional quality, but data on associations with biomarkers are scarce. We aimed to explore associations between UPF intake, diet quality, and concentrations of biomarkers of nutrition and inflammation measur...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1052001/full |
| _version_ | 1811185587664715776 |
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| author | Pieta Tasnim Kelsey Pieta Tasnim Kelsey Eleni Papadopoulou Tiril Cecilie Borge Cecilie Dahl Anne Lise Brantsæter Iris Erlund Helle Margrete Meltzer Line Småstuen Haug Ida Henriette Caspersen |
| author_facet | Pieta Tasnim Kelsey Pieta Tasnim Kelsey Eleni Papadopoulou Tiril Cecilie Borge Cecilie Dahl Anne Lise Brantsæter Iris Erlund Helle Margrete Meltzer Line Småstuen Haug Ida Henriette Caspersen |
| author_sort | Pieta Tasnim Kelsey |
| collection | DOAJ |
| description | BackgroundA high consumption of ultra-processed foods (UPFs) is often associated with low nutritional quality, but data on associations with biomarkers are scarce. We aimed to explore associations between UPF intake, diet quality, and concentrations of biomarkers of nutrition and inflammation measured in mid-pregnancy.MethodsThis cross-sectional study included n = 2,984 pregnant women recruited during 2002–2008 in the Norwegian Mother, Father, and Child Cohort Study (MoBa). Concentrations of C-reactive protein (CRP) and 21 nutritional biomarkers including carotenes (α-carotene, β-carotene, γ-carotene, α-cryptoxanthin, β-cryptoxanthin, lutein, lycopene), vitamins [α-tocopherol, γ-tocopherol, 25-hydroxyvitamin D (25-OH-D), retinol], creatinine, elements (K, Na, Co, Cu, Mn, Mo, Se, Zn), and ferritin (Fe) were measured in blood and urine collected in mid-pregnancy. Habitual diet in pregnancy was assessed using a validated semi-quantitative food frequency questionnaire. We calculated the relative (%) energy contribution of UPF to overall intake according to the NOVA classification. We also applied a diet quality index (DQI) adapted to assess adherence to Norwegian dietary guidelines (DQI; min–max: 0–110, higher score meaning higher adherence). We present summary statistics for biomarker concentrations and explored associations between UPF intake or the DQI and measured biomarkers using adjusted linear, logistic, and generalized additive regression models.ResultsUltra-processed food intake was positively associated with biomarker concentrations of vitamin E (γ-tocopherol), creatinine, K, and Na [βs: 5.6 to 17% increase in biomarker concentration per interquartile range (IQR) increase in UPF intake] and negatively associated with carotenoids (α-carotene, β-carotene, γ-carotene, α-cryptoxanthin, β-cryptoxanthin, lutein, lycopene), vitamin A, Mo, and Se (βs: −2.1 to −18%). Inversely, high diet quality (i.e., the DQI) was positively associated with concentrations of carotenoids, vitamins [vitamin A (retinol) and D (25-OH-D)], and Se (β: 1.5 to 25%) and negatively associated with vitamin E (γ-tocopherol), creatinine, and Na (β: −4.8 to −8.3%). A weak, positive association was found between UPF and CRP (β: 5.4%, 95% CI 0.12–11%).ConclusionHigh UPF intake was associated with reduced concentrations of nutrition biomarkers in mid-pregnancy. Associations in the opposite direction were found with high adherence to the Norwegian dietary guidelines, suggesting that the two dietary scoring systems capture diet quality in a mirrored manner in this population. |
| first_indexed | 2024-04-11T13:32:59Z |
| format | Article |
| id | doaj.art-26274082201f42a09eb4ba90908bc152 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T13:32:59Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-26274082201f42a09eb4ba90908bc1522022-12-22T04:21:43ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-12-01910.3389/fnut.2022.10520011052001Ultra-processed food consumption and associations with biomarkers of nutrition and inflammation in pregnancy: The Norwegian Environmental BiobankPieta Tasnim Kelsey0Pieta Tasnim Kelsey1Eleni Papadopoulou2Tiril Cecilie Borge3Cecilie Dahl4Anne Lise Brantsæter5Iris Erlund6Helle Margrete Meltzer7Line Småstuen Haug8Ida Henriette Caspersen9Division of Climate and Environmental Health, Department of Food Safety, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, NorwayGlobal Health Cluster, Division for Health Services, Norwegian Institute of Public Health, Oslo, NorwayCluster for Reviews and Health Technology Assessments, Division for Health Services, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, NorwayDivision of Climate and Environmental Health, Department of Food Safety, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Government Services, Finnish Institute for Health and Welfare, Helsinki, FinlandDivision of Climate and Environmental Health, Department of Food Safety, Norwegian Institute of Public Health, Oslo, NorwayDivision of Climate and Environmental Health, Department of Food Safety, Norwegian Institute of Public Health, Oslo, NorwayCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, NorwayBackgroundA high consumption of ultra-processed foods (UPFs) is often associated with low nutritional quality, but data on associations with biomarkers are scarce. We aimed to explore associations between UPF intake, diet quality, and concentrations of biomarkers of nutrition and inflammation measured in mid-pregnancy.MethodsThis cross-sectional study included n = 2,984 pregnant women recruited during 2002–2008 in the Norwegian Mother, Father, and Child Cohort Study (MoBa). Concentrations of C-reactive protein (CRP) and 21 nutritional biomarkers including carotenes (α-carotene, β-carotene, γ-carotene, α-cryptoxanthin, β-cryptoxanthin, lutein, lycopene), vitamins [α-tocopherol, γ-tocopherol, 25-hydroxyvitamin D (25-OH-D), retinol], creatinine, elements (K, Na, Co, Cu, Mn, Mo, Se, Zn), and ferritin (Fe) were measured in blood and urine collected in mid-pregnancy. Habitual diet in pregnancy was assessed using a validated semi-quantitative food frequency questionnaire. We calculated the relative (%) energy contribution of UPF to overall intake according to the NOVA classification. We also applied a diet quality index (DQI) adapted to assess adherence to Norwegian dietary guidelines (DQI; min–max: 0–110, higher score meaning higher adherence). We present summary statistics for biomarker concentrations and explored associations between UPF intake or the DQI and measured biomarkers using adjusted linear, logistic, and generalized additive regression models.ResultsUltra-processed food intake was positively associated with biomarker concentrations of vitamin E (γ-tocopherol), creatinine, K, and Na [βs: 5.6 to 17% increase in biomarker concentration per interquartile range (IQR) increase in UPF intake] and negatively associated with carotenoids (α-carotene, β-carotene, γ-carotene, α-cryptoxanthin, β-cryptoxanthin, lutein, lycopene), vitamin A, Mo, and Se (βs: −2.1 to −18%). Inversely, high diet quality (i.e., the DQI) was positively associated with concentrations of carotenoids, vitamins [vitamin A (retinol) and D (25-OH-D)], and Se (β: 1.5 to 25%) and negatively associated with vitamin E (γ-tocopherol), creatinine, and Na (β: −4.8 to −8.3%). A weak, positive association was found between UPF and CRP (β: 5.4%, 95% CI 0.12–11%).ConclusionHigh UPF intake was associated with reduced concentrations of nutrition biomarkers in mid-pregnancy. Associations in the opposite direction were found with high adherence to the Norwegian dietary guidelines, suggesting that the two dietary scoring systems capture diet quality in a mirrored manner in this population.https://www.frontiersin.org/articles/10.3389/fnut.2022.1052001/fullpregnancyC-reactive proteinferritincarotenoidsvitaminsessential elements |
| spellingShingle | Pieta Tasnim Kelsey Pieta Tasnim Kelsey Eleni Papadopoulou Tiril Cecilie Borge Cecilie Dahl Anne Lise Brantsæter Iris Erlund Helle Margrete Meltzer Line Småstuen Haug Ida Henriette Caspersen Ultra-processed food consumption and associations with biomarkers of nutrition and inflammation in pregnancy: The Norwegian Environmental Biobank Frontiers in Nutrition pregnancy C-reactive protein ferritin carotenoids vitamins essential elements |
| title | Ultra-processed food consumption and associations with biomarkers of nutrition and inflammation in pregnancy: The Norwegian Environmental Biobank |
| title_full | Ultra-processed food consumption and associations with biomarkers of nutrition and inflammation in pregnancy: The Norwegian Environmental Biobank |
| title_fullStr | Ultra-processed food consumption and associations with biomarkers of nutrition and inflammation in pregnancy: The Norwegian Environmental Biobank |
| title_full_unstemmed | Ultra-processed food consumption and associations with biomarkers of nutrition and inflammation in pregnancy: The Norwegian Environmental Biobank |
| title_short | Ultra-processed food consumption and associations with biomarkers of nutrition and inflammation in pregnancy: The Norwegian Environmental Biobank |
| title_sort | ultra processed food consumption and associations with biomarkers of nutrition and inflammation in pregnancy the norwegian environmental biobank |
| topic | pregnancy C-reactive protein ferritin carotenoids vitamins essential elements |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1052001/full |
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