New Multidrug Efflux Inhibitors for Gram-Negative Bacteria

New Multidrug Efflux Inhibitors for Gram-Negative Bacteria

ABSTRACT Active efflux of antibiotics preventing their accumulation to toxic intracellular concentrations contributes to clinically relevant multidrug resistance. Inhibition of active efflux potentiates antibiotic activity, indicating that efflux inhibitors could be used in combination with antibiot...

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Bibliographic Details
Main Authors: Robert L. Marshall, Georgina S. Lloyd, Amelia J. Lawler, Sarah J. Element, Jaswant Kaur, Maria Laura Ciusa, Vito Ricci, Andreas Tschumi, Holger Kühne, Luke J. Alderwick, Laura J. V. Piddock
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
efflux inhibitors
GFP
high throughput
RamA
Online Access:https://journals.asm.org/doi/10.1128/mBio.01340-20

Internet

https://journals.asm.org/doi/10.1128/mBio.01340-20

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